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RESEARCH UPDATE
   


St. Nicholas Home > Research Update

Research

$300,000 CIHR Grant Awarded To Medicago, The Research Institute Of The MUHC And McGill University

The Canadian Institutes of Health Research (CIHR) have awarded a $300,000 grant for research focusing on the nature of the immune response induced by the action mechanisms of plant-made Virus-Like Particles (VLP) to Dr. Louis Vezina, Chief Scientific Officer of Medicago and to Dr. Brian Ward and Dr...

http://mnt.to/f/3yng

Inovio Biomedical H5N1 Avian Influenza DNA Vaccine Receives Korean Approval To Begin Clinical Trials

Inovio Biomedical Corporation (NYSE Amex: INO), a leader in DNA vaccine design, development and delivery, announced that its affiliate VGX International Inc. (Korean Stock Exchange: 011000) has received approval in Korea to begin a Phase I clinical trial in healthy volunteers for Inovio's SynCon™ preventive DNA vaccine (VGX-3400) targeting H5N1 avian influenza...

http://mnt.to/f/3yn2

News From The Journals Of The American Society For Microbiology

Campylobacter Bacteria in Cattle Manure May Survive Composting Contrary to popular belief, some disease causing bacteria may actually survive the composting process...

http://mnt.to/f/3y98


Male Batterers Consistently Overestimate General Rates Of Violence Toward Partners

Men who engaged in domestic violence consistently overestimated how common such behavior is, and the more they overestimated it the more they engaged in abusing their partner in the previous 90 days, according to new research conducted at the University of Washington...

http://mnt.to/f/3yKD

U.N. Official Addresses Increasing Drug Addiction In Developing Countries

The U.N. Office on Drugs and Crime (UNODC) on Monday warned of an impending "health disaster facing developing countries if wealthy nations fail to control drugs," Agence France-Presse reports...

http://mnt.to/f/3yJX

Violent Crime 'Race Gap' Narrows, But Persists In U.S.

The U.S. 'race gap' in the commission of violent crime has narrowed substantially, yet persists - with murder arrest rates for African Americans still out-distancing those for whites - concludes a new 80-city study by the University of Maryland, Florida State University and the University of Oregon...

http://mnt.to/f/3yGP


Meat And Colorectal Cancer Risk: Scientists Suggest Potential Mechanisms

Scientists in the US who undertook a large study to investigate what biological mechanisms might be behind the already established link between colorectal cancer and consumption of red and processed meat, confirmed that such a link exists and suggested the main players are three compounds: heme iron, nitrate/nitrite, and heterocyclic amines...

http://mnt.to/f/3yLK

2010 Recipient Of Minority Scholar Award Will Conduct Clinical Research On Leukemia

Alison Walker, MD, has been selected to receive the ASH-AMFDP Award, and will begin her research in acute myeloid leukemia in July of this year...

http://mnt.to/f/3yKv

Research Identifies New Mechanism Regulating Embryonic Development

A Princeton University-led research team has discovered that protein competition over an important enzyme provides a mechanism to integrate different signals that direct early embryonic development. The work suggests that these signals are combined long before they interact with the organism's DNA, as was previously believed, and also may inform new therapeutic strategies to fight cancer...

http://mnt.to/f/3yKL


Food Aid Phase Over For Haiti, Focus Should Be On Jobs, Hurricane Season Preparation, Schools, Haitian President Says

At their meeting on Wednesday, Haitian President Rene Preval is expected to ask President Barack Obama to stop food aid to Haiti, Reuters reports. "Preval told a news conference on Monday the aid could in the long term hurt the economy of the poorest country in the Western Hemisphere...

http://mnt.to/f/3yJT

Haiti Relief Operations Supported By Navy Scientists

Scientists at the Naval Research Laboratory at Stennis Space Center are supporting Haiti relief operations...

http://mnt.to/f/3yGB

Tetanus, Hepatitis Vaccination Campaign Launched In Chile Amid Fears Of Disease Outbreaks

"Chile launched a hepatitis and tetanus vaccination campaign Friday and doctors warned of outbreaks of diarrhea and infection among thousands of people displaced by the earthquake and the tsunami that heavily damaged or destroyed 36 hospitals and made garbage dumps of coastal towns and cities," the Associated Press reports...

http://mnt.to/f/3yFM


How Breast Cancer Patients Want to Search for and Retrieve Information From Stories of Other Patients on the Internet: an Online Randomized Controlled Experiment

Background: Other patients’ stories on the Internet can give patients information, support, reassurance, and practical advice. Objective: We examined which search facility for online stories resulted in patients’ satisfaction and search success. Methods: This study was a randomized controlled experiment with a 2x2 factorial design conducted online. We facilitated access to 170 stories of breast cancer patients in four ways based on two factors: (1) no versus yes search by story topic, and (2) no versus yes search by writer profile. Dutch speaking women with breast cancer were recruited. Women who gave informed consent were randomly assigned to one of four groups. After searching for stories, women were offered a questionnaire relating to satisfaction with the search facility, the stories retrieved, and impact of the stories on coping with breast cancer. Of 353 enrolled women, 182 (51.6%) completed the questionnaire: control group (n = 37), story topics group (n = 49), writer profile group (n = 51), and combination group (n = 45). Results: Questionnaire completers were evenly distributed over the four groups (χ23 = 3.7, P = .30). Women who had access to the story topics search facility (yes vs no): were more positive about (mean scores 4.0 vs 3.6, P = .001) and more satisfied with the search facility (mean scores 7.3 vs 6.3, P < .001); were more positive about the number of search options (mean scores 2.3 vs 2.1,P = .04); were better enabled to find desired information (mean scores 3.3 vs 2.8, P = .001); were more likely to recommend the search facility to others or intend to use it themselves (mean scores 4.1 vs 3.5, P < .001); were more positive about how retrieved stories were displayed (mean scores 3.6 vs 3.2, P = .001); retrieve stories that better covered their information needs (mean scores 3.0 vs 2.6, P = .02); were more satisfied with the stories retrieved (mean scores 7.1 vs 6.4, P = .002); and were more likely to report an impact of the stories on coping with breast cancer (mean scores 3.2 vs 2.9, P =. 02). Three main effects were associated with use of the writer profile search (yes vs no): being more positive about (mean scores 3.9 vs 3.6, P = .005) and more satisfied with the search facility (mean scores 7.1 vs 6.5, P =. 01), and being more positive about how retrieved stories were displayed (mean scores 3.8 vs 2.9, P < .001). For satisfaction with the search facility, an interaction effect was found (P = .03): at least one of the two search facilities was needed for satisfaction. Conclusions: Having access to the story topics search facility clearly had the most positive effect on patient satisfaction and search success.

http://www.jmir.org/2010/1/e7

Physician Order Entry Or Nurse Order Entry? Comparison of Two Implementation Strategies for a Computerized Order Entry System Aimed at Reducing Dosing Medication Errors

Background: Despite the significant effect of computerized physician order entry (CPOE) in reducing nonintercepted medication errors among neonatal inpatients, only a minority of hospitals have successfully implemented such systems. Physicians' resistance and users' frustration seem to be two of the most important barriers. One solution might be to involve nurses in the order entry process to reduce physicians’ data entry workload and resistance. However, the effect of this collaborative order entry method in reducing medication errors should be compared with a strictly physician order entry method. Objective: To investigate whether a collaborative order entry method consisting of nurse order entry (NOE) followed by physician verification and countersignature is as effective as a strictly physician order entry (POE) method in reducing nonintercepted dose and frequency medication errors in the neonatal ward of an Iranian teaching hospital. Methods: A four-month prospective study was designed with two equal periods. During the first period POE was used and during the second period NOE was used. In both methods, a warning appeared when the dose or frequency of the prescribed medication was incorrect that suggested the appropriate dosage to the physicians. Physicians’ responses to the warnings were recorded in a database and subsequently analyzed. Relevant paper-based and electronic medical records were reviewed to increase credibility. Results: Medication prescribing for 158 neonates was studied. The rate of nonintercepted medication errors during the NOE period was 40% lower than during the POE period (rate ratio 0.60; 95% confidence interval [CI] .50, .71;P < .001). During the POE period, 80% of nonintercepted errors occurred at the prescription stage, while during the NOE period, 60% of nonintercepted errors occurred in that stage. Prescription errors decreased from 10.3% during the POE period to 4.6% during the NOE period (P < .001), and the number of warnings with which physicians complied increased from 44% to 68% respectively (P < .001). Meanwhile, transcription errors showed a nonsignificant increase from the POE period to the NOE period. The median error per patient was reduced from 2 during the POE period to 0 during the NOE period (P = .005). Underdose and curtailed and prolonged interval errors were significantly reduced from the POE period to the NOE period. The rate of nonintercepted overdose errors remained constant between the two periods. However, the severity of overdose errors was lower in the NOE period (P = .02). Conclusions: NOE can increase physicians' compliance with warnings and recommended dose and frequency and reduce nonintercepted medication dosing errors in the neonatal ward as effectively as POE or even better. In settings where there is major physician resistance to implementation of CPOE, and nurses are willing to participate in the order entry and are capable of doing so, NOE may be considered a beneficial alternative order entry method.

http://www.jmir.org/2010/1/e5

Using the Internet to Promote Health Behavior Change: A Systematic Review and Meta-analysis of the Impact of Theoretical Basis, Use of Behavior Change Techniques, and Mode of Delivery on Efficacy

Background: The Internet is increasingly used as a medium for the delivery of interventions designed to promote health behavior change. However, reviews of these interventions to date have not systematically identified intervention characteristics and linked these to effectiveness. Objectives: The present review sought to capitalize on recently published coding frames for assessing use of theory and behavior change techniques to investigate which characteristics of Internet-based interventions best promote health behavior change. In addition, we wanted to develop a novel coding scheme for assessing mode of delivery in Internet-based interventions and also to link different modes to effect sizes. Methods: We conducted a computerized search of the databases indexed by ISI Web of Knowledge (including BIOSIS Previews and Medline) between 2000 and 2008. Studies were included if (1) the primary components of the intervention were delivered via the Internet, (2) participants were randomly assigned to conditions, and (3) a measure of behavior related to health was taken after the intervention. Results: We found 85 studies that satisfied the inclusion criteria, providing a total sample size of 43,236 participants. On average, interventions had a statistically small but significant effect on health-related behavior (d+ = 0.16, 95% CI 0.09-0.23). More extensive use of theory was associated with increases in effect size (P = .049), and, in particular, interventions based on the theory of planned behavior tended to have substantial effects on behavior (d+ = 0.36, 95% CI 0.15-0.56). Interventions that incorporated more behavior change techniques also tended to have larger effects compared to interventions that incorporated fewer techniques (P < .001). Finally, the effectiveness of Internet-based interventions was enhanced by the use of additional methods of communicating with participants, especially the use of short message service (SMS), or text, messages. Conclusions: The review provides a framework for the development of a science of Internet-based interventions, and our findings provide a rationale for investing in more intensive theory-based interventions that incorporate multiple behavior change techniques and modes of delivery.

http://www.jmir.org/2010/1/e4


Diamyd Medical: Diamyd US Phase III Study Well Under Way

Diamyd Medical (STO:DIAMB)(Pink Sheets:DMYDY) announces today that one hundred study participants have been included in the ongoing US Phase III study, DiaPrevent. The global Phase III program with the company's lead drug candidate Diamyd® has thereby enrolled more than 430 children newly diagnosed with type 1 diabetes in Europe and the USA. One hundred patients are now enrolled in the company's US Phase III study called DiaPrevent at 33 diabetes centers throughout the USA and more sites will be added...


http://feedproxy.google.com/~r/mnt/healthnews/~3/apHjpF1jOpw/3yKP

WHO Releases New Malaria Guidelines For Treatment And Procurement Of Medicines

The World Health Organization (WHO) is releasing new guidelines for the treatment of malaria, and the first ever guidance on procuring safe and efficacious anti-malarial medicines. In recent years a new type of treatment called artemisinin-based combination therapy (ACTs) has transformed the treatment of malaria, but if not used properly the medicine could become ineffective. Guidelines emphasize testing The Guidelines for the Treatment of Malaria (second edition) provide evidence-based and current recommendations for countries on malaria diagnosis and treatment...


http://feedproxy.google.com/~r/mnt/healthnews/~3/REF0C114q_M/3yKJ

Ag Groups Weigh-in On Supreme Court Case For Biotech Alfalfa

The U.S. Supreme Court will decide whether a lower court acted hastily and incorrectly by banning the cultivation of biotech alfalfa despite extensive scientific evidence documenting the safety of the crop. A coalition of agricultural organizations filed on March 8 a joint friend-of-the-court brief to the Supreme Court in support of the petitioners in "Monsanto Co. v. Geertson Seed Farms...


http://feedproxy.google.com/~r/mnt/healthnews/~3/Ljk9EFLZKgw/3yKG


Diamyd Medical: Diamyd US Phase III Study Well Under Way

Diamyd Medical (STO:DIAMB)(Pink Sheets:DMYDY) announces today that one hundred study participants have been included in the ongoing US Phase III study, DiaPrevent. The global Phase III program with the company's lead drug candidate Diamyd® has thereby enrolled more than 430 children newly diagnosed with type 1 diabetes in Europe and the USA...

http://mnt.to/f/3yKP

Link Between Obesity And Poor Colon Cancer Prognosis

Obese patients with colon cancer are at greater risk for death or recurrent disease compared to those who are within a normal weight range, according to a report in Clinical Cancer Research, a journal of the American Association for Cancer Research...

http://mnt.to/f/3yK9

Cellectar Completes Enrollment In Phase I Clinical Trial Of Lead Drug Candidate (131)I-CLR1404 For The Treatment Of Solid Malignancies

Cellectar, Inc., a privately held radiopharmaceutical company that designs and develops products to detect, treat and monitor human cancers, announced that enrollment for its Phase I dosimetry trial for its lead drug candidate, (131)I-CLR1404 has been completed. Results of this trial will be used to set the starting dose in a follow-on Phase I dose escalation study planned for later this year...

http://mnt.to/f/3yJ7


Diamyd Medical: Diamyd US Phase III Study Well Under Way

Diamyd Medical (STO:DIAMB)(Pink Sheets:DMYDY) announces today that one hundred study participants have been included in the ongoing US Phase III study, DiaPrevent. The global Phase III program with the company's lead drug candidate Diamyd® has thereby enrolled more than 430 children newly diagnosed with type 1 diabetes in Europe and the USA...

http://mnt.to/f/3yKP

Hepatitis C And Insulin Resistance - Surprising Findings

We have known for several years that Hepatitis C, a common cause of liver cirrhosis and cancer, also makes people three to four times more likely to develop Type 2 diabetes. In studying the insulin resistance of 29 people with Hepatitis C, Australian researchers have confirmed that they have high insulin resistance, a precursor to diabetes...

http://mnt.to/f/3yK3

Starting Treatment Early Doubles Chance Of Success For People With Diabetes

The sooner people with diabetes start taking metformin, the longer the drug remains effective, according to a Kaiser Permanente study published in the March issue of Diabetes Care, a journal of the American Diabetes Association...

http://mnt.to/f/3yJ2
 
 
   
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